Streptomycesis the largest antibiotic-producing genus, producing antibacterial, antifungal, and antiparasitic drugs, and also a wide range of other bioactive compounds, such asimmuno suppressants. Streptomyces avermitilis is a bacteria that is responsible for producing avermectin, most widely used drugs against nematode and arthropod infestations.

Proactive is a derivative of avermectin B1, that is broad spectrum, ultra-high efficiency insecticide that acts by contact and as stomach posion.